高频振荡通气联合肺表面活性物质对NRDS患儿血流动力学、氧合功能及炎症因子水平的影响.

Objective: To investigate the effects of high frequency oscillatory ventilation (HFOV) combined with pulmonary surfactant (PS) on hemodynamics, oxygenation and levels of inflammatory factors in neonatal respiratory distress syndrome (NRDS). Methods: 129 children with NRDS received in our hospital from June 2016 to April 2019 were selected, and the children were divided into study group (n=65) and control group (n=64) according to the random number table method. On this basis, children in the control group were treated with constant frequency mechanical ventilation (CMV), and the study group was treated with HFOV. The curative effect, hemodynamics, oxygenation function, inflammatory factor levels and complications of the two groups were compared. Symptoms occurred. Results: The total clinical effective rate of the study group after 24 hours of treatment was 89.23% (58/65), which was higher than the control group's 68.75% (44/64) (P<0.05). The arterial blood oxygen partial pressure (PaO2 ) increased after 24 hours of treatment in the two groups, and the study group was higher than the control group (P<0.05); heart rate (HR), pulmonary artery pressure (PAP), interleukin-6 (IL-6) ), procalcitonin (PCT), high-sensitivity C-reactive protein (hs-CRP), arterial partial pressure of carbon dioxide (PaCO2 ), oxygenation index (OI) all decreased, and the study group was lower than the control group (P<0.05 ). There was no significant difference in the total incidence of complications between the two groups (P>0.05). Conclusion: HFOV combined with PS in the treatment of NRDS can effectively improve the hemodynamics, oxygenation function and inflammatory factor levels in children, without increasing the incidence of complications, and has high clinical application value. [ABSTRACT FROM AUTHOR]