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Synthesis and Properties of N,N′-Disubstituted Ureas and Their Isosteric Analogs Containing Polycyclic Fragments: VIII. Synthesis and Properties of N-[(3-Chloroadamantan-1-yl)methyl]-N′-(Fluoro, chlorophenyl)ureas and Symmetrical Bis-ureas.
- Source :
-
Russian Journal of Organic Chemistry . Mar2021, Vol. 57 Issue 3, p327-337. 11p. - Publication Year :
- 2021
-
Abstract
- A new procedure has been proposed for the synthesis of 3-chloroadamantan-1-ylmethyl isocyanate starting from 2-(3-chloroadamantan-1-yl)acetic acid. Reactions of 3-chloroadamantan-1-ylmethyl isocyanate with fluoro- and chloroanilines and alkane-α,ω-diamines afforded two series of N,N′-disubstituted ureas containing a 3-chloroadamantan-1-yl substituent in 53–94% yields. The synthesized ureas are promising as inhibitors of human soluble epoxide hydrolase. [ABSTRACT FROM AUTHOR]
- Subjects :
- *ISOCYANATES
*EPOXIDE hydrolase
*UREA
*ACETIC acid
Subjects
Details
- Language :
- English
- ISSN :
- 10704280
- Volume :
- 57
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- Russian Journal of Organic Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 149617112
- Full Text :
- https://doi.org/10.1134/S1070428021030027