QSER1 protects DNA methylation valleys from de novo methylation.

The article discusses that DNA methylation is required for mammalian development, and dysregulation of the same lead to pathological conditions, like immunodeficiency-centromeric instability-facial anomalies syndrome (ICF) and microcephalic dwarfism. The enzymes are responsible for the addition and removal of DNA methylation but their cordination is in question.