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Study on the Influencing Factors of Hypoglycemic Effect of Folate Targeted Polymersomes Encapsulating Insulin.
- Source :
-
Journal of Pharmaceutical Sciences . May2021, Vol. 110 Issue 5, p2105-2113. 9p. - Publication Year :
- 2021
-
Abstract
- To study the effects of the density of folic acid (FA) on the hypoglycemic ability of FA-targeted polymersomes as oral insulin carriers. Also to study the change of the hypoglycemic effect of FA-targeted mixed polymersomes added with various mass ratio of d -α-tocopherol polyethylene glycol 1000 succinate (TPGS). The FA-targeted polymersomes with different FA molar contents were prepared. The in vitro insulin release experiments in different media for FA-targeted polymersomes with various FA contents were studied. Their quantitative cellular uptake in Caco-2 cells was examined. The in vivo hypoglycemic activity of FA-targeted polymersomes was also studied with diabetic rats. The polymersomes with the optimal FA molar content was chosen to prepare mixed polymersomes with various TPGS contents. Among insulin-loaded FA-targeted polymersomes with four different FA molar contents, insulin-loaded polymersomes with 10% FA molar content (insulin-loaded 10%FA-Ps) showed the hightest cellular uptake and the best hypoglycemic response. In addition, the insulin-loaded FA-Ps/TPGS5:1 mixed polymersomes exhibited higher cellular uptake and better hypoglycemic response than the other two insulin-loaded mixed polymersomes adding TPGS did. FA-Ps/TPGS5:1 could be a promising formulation for the oral administration of insulin. [ABSTRACT FROM AUTHOR]
- Subjects :
- *INSULIN
*POLYETHYLENE glycol
*POLYMERSOMES
*FOLIC acid
Subjects
Details
- Language :
- English
- ISSN :
- 00223549
- Volume :
- 110
- Issue :
- 5
- Database :
- Academic Search Index
- Journal :
- Journal of Pharmaceutical Sciences
- Publication Type :
- Academic Journal
- Accession number :
- 149779188
- Full Text :
- https://doi.org/10.1016/j.xphs.2020.11.042