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Reduced neutralization of SARS-CoV-2 B.1.1.7 variant by convalescent and vaccine sera.
- Source :
-
Cell . Apr2021, Vol. 184 Issue 8, p2201-2201. 1p. - Publication Year :
- 2021
-
Abstract
- SARS-CoV-2 has caused over 2 million deaths in little over a year. Vaccines are being deployed at scale, aiming to generate responses against the virus spike. The scale of the pandemic and error-prone virus replication is leading to the appearance of mutant viruses and potentially escape from antibody responses. Variant B.1.1.7, now dominant in the UK, with increased transmission, harbors 9 amino acid changes in the spike, including N501Y in the ACE2 interacting surface. We examine the ability of B.1.1.7 to evade antibody responses elicited by natural SARS-CoV-2 infection or vaccination. We map the impact of N501Y by structure/function analysis of a large panel of well-characterized monoclonal antibodies. B.1.1.7 is harder to neutralize than parental virus, compromising neutralization by some members of a major class of public antibodies through light-chain contacts with residue 501. However, widespread escape from monoclonal antibodies or antibody responses generated by natural infection or vaccination was not observed. [Display omitted] • Original strain convalescent and vaccine sera show reduced B.1.1.7 neutralization • N501Y enhances RBD: ACE2 binding affinity • N501Y compromises neutralization by many antibodies with public V-region IGHV3-53 • No widespread escape by B.1.1.7 was observed The SARS-CoV-2 B.1.1.7 variant is not neutralized as easily as the original form of the virus. Some public antibodies cannot neutralize B.1.1.7, due to altered light-chain contacts with residue 501. However, B.1.1.7 does not show widespread escape from monoclonal antibodies, natural antibody responses, or vaccines. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00928674
- Volume :
- 184
- Issue :
- 8
- Database :
- Academic Search Index
- Journal :
- Cell
- Publication Type :
- Academic Journal
- Accession number :
- 149781649
- Full Text :
- https://doi.org/10.1016/j.cell.2021.02.033