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Antibodies to MOG in CSF only: pathological findings support the diagnostic value.
- Source :
-
Acta Neuropathologica . May2021, Vol. 141 Issue 5, p801-804. 4p. - Publication Year :
- 2021
-
Abstract
- Scarce pathological brain evaluations confirmed the distinct entity of MOG-Abs-associated disorders (MOGAD), characterised by relative axonal sparing, perivenous, subpial, cortical and confluent primary demyelination, reactive gliosis, and inflammatory infiltrates predominantly constituted by granulocytes, macrophages, and CD4 + T cells [[2], [6]]. Spinal cord MRI showed multiple short T2-hyperintense lesions involving the spinal cord from the cranio-cervical junction to T12 and a central tumefactive lesion extending longitudinally from T9 to the conus (Fig. Antibodies to myelin oligodendrocyte glycoprotein (MOG-Abs) define a distinct entity of inflammatory CNS diseases, commonly presenting with subacute optic neuritis and/or myelitis in adults and encephalomyelitis in children [[5]]. We herein report the first autoptic findings of brain, spinal cord, nerve roots, and leptomeninges of a patient with MOG-Abs positivity in CSF only. [Extracted from the article]
Details
- Language :
- English
- ISSN :
- 00016322
- Volume :
- 141
- Issue :
- 5
- Database :
- Academic Search Index
- Journal :
- Acta Neuropathologica
- Publication Type :
- Academic Journal
- Accession number :
- 149789222
- Full Text :
- https://doi.org/10.1007/s00401-021-02286-3