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Prevalence and factors associated with anxiety and depressive symptoms among patients hospitalized with hematological malignancies after chimeric antigen receptor T-cell (CAR-T) therapy: A cross-sectional study.
- Source :
-
Journal of Affective Disorders . May2021, Vol. 286, p33-39. 7p. - Publication Year :
- 2021
-
Abstract
- <bold>Background: </bold>We conducted a survey to investigate the prevalence and factors associated with anxiety and depressive symptoms among patients hospitalized with hematological malignancies after chimeric antigen receptor T-cell (CAR-T) therapy.<bold>Methods: </bold>In total, 130 eligible patients completed the Self-Rating Anxiety Scale and Self-Rating Depression Scale at week 4 after CAR-T cell infusion. We collected sociodemographic information during the same period. We studied factors associated with anxiety and depressive symptoms using logistic regression analysis.<bold>Results: </bold>The prevalence of anxiety and depressive symptoms at week 4 after infusion were 13.8% and 40.0%, respectively. A cutoff value of 50 or above indicates significantly anxiety and depressive symptoms. Binary logistic regression analysis showed that high school education and above (OR = 0.22, 95% CI = 0.06-0.78) and middle age (OR = 0.16, 95% CI = 0.03-0.90) were associated with lower risk of anxiety symptoms, and increased odds of depressive symptoms was associated with old age (OR = 11.39, 95% CI = 2.50-51.88), non-manual occupations before illness (OR = 3.72, 95% CI = 1.20-11.58), and higher healthcare expenditure (OR = 3.93, 95% CI = 1.50-10.33), while lower risk of depressive symptoms was associated with rural household location (OR = 0.25, 95% CI = 0.08-0.76) and being cared for by spouse (OR = 0.12, 95% CI = 0.02-0.63).<bold>Conclusions: </bold>Patients receiving CAR-T therapy with lower education background, old ages, urban household location, or who used to work as non-manual workers require more attention and psychological care. Support from a spouse and medical expense deductions from the government may help patients develop positive attitudes. [ABSTRACT FROM AUTHOR]
- Subjects :
- *MENTAL depression
*CHIMERIC antigen receptors
*ANXIETY
*REMINISCENCE therapy
*LOGISTIC regression analysis
*CROSS-sectional method
*RESEARCH
*RESEARCH methodology
*MEDICAL cooperation
*EVALUATION research
*SELF-report inventories
*ANXIETY testing
*COMPARATIVE studies
*HEMATOLOGIC malignancies
*DISEASE prevalence
*T cells
Subjects
Details
- Language :
- English
- ISSN :
- 01650327
- Volume :
- 286
- Database :
- Academic Search Index
- Journal :
- Journal of Affective Disorders
- Publication Type :
- Academic Journal
- Accession number :
- 149803389
- Full Text :
- https://doi.org/10.1016/j.jad.2021.02.041