Candida-spezifische Antikörper bei Intensivtherapiepatienten und Nichtintensivtherapiepatienten.

The titres of indirect anti-Candidahaemagglutination test (C-HAT) and specific immunoglobulins C-IgM, C-IgG and C-IgA in 328 intensive care (IT) patients and 166 non-intensive care (NIT) patients were compared by statistical test methods. Positive correlations were found between values of C-HAT and all threeCandida-specific immunoglobulins. At an interval of≤7 days in the first patient group only, the changes in the course of titres were statistically highly significant. For C-IgM the short-term increase of titres can be interpreted in the sense of happened mycotic infection in connection with the clinical picture. In IT patients we found an average increase of C-IgM at 259.3, C-IgG at 174.7, C-IgA at 59.8 U ml−1 and of three titre steps in C-HAT. In our experience of diagnostics ofCandidainfections in intensive care area with non-neutropenic patients the short-term determination of the anti-Candidaimmunoglobulin subclasses C-IgM and C-IgG and of C-HAT as screening test should not be neglected. [ABSTRACT FROM AUTHOR]