Identifying "more equal than others" edges in diverse biochemical networks.

Thisredundancyissuggestedbyobservations that demonstrate the presence of canalization in biochemical networks [as proposed by Waddington earlier (10)], where only a few dynamic perturbations to the network can alter the emergent network properties (11). (B) The corresponding effective graph representing the effectiveness score ofeachofthesixedges.(C)Look-uptruthtablecorrespondingtothe network inA.(D) Characterizing effectiveness of edges to nodes A andC.#(wildcard)representstheactivityofthenodewhichdoesnot affect the network output. Therefore, the effective graph may be more informative in terms of identifying the Achilles' heel in a regulatory network, reminiscent of another network reduction method to arrive at an "influence matrix" for a specific network (15). [Extracted from the article]