Correlation and prognostic impact of human papilloma virus and p16-expression in advanced hypopharynx and larynx cancer treated with definitive radiotherapy.

The article focuses on correlation and prognostic impact of human papilloma virus and p16-expression in advanced hypopharynx and larynx cancer treated with definitive radiotherapy. Topics include the human papilloma virus (HPV) is a well-established aetiological factor in oropharynx cancer (OPC), the global variation in the incidence of HPV plus OPC is considerable, and the countries with high age standardized incidence rates of the disease are located in Northern America and Europe.