消退素在牙髓、根尖周及牙周组织炎症环境中的活髓保存及再生作用.

BACKGROUND: Bacterial infection is an important cause of infection of the dental pulp and periapical tissue. Vital pulp conservation and regeneration of the dental pulp are becoming new clinical strategies for the treatment of pulp and periapical diseases. Resolvin is a lipid mediator derived from omega-3 polyunsaturated fatty acids. It promotes the resolution of tissue inflammation and the recovery of inflammatory conditions. OBJECTIVE: To review the research progress in the effect of resolvin in inflammation regulation and its application in the inflammation of dental pulp, periapical and periodontal tissues, providing evidence for inflammatory recovery and regeneration of the dental pulp. METHODS: PubMed, VIP, WanFang and CNKI were searched for relevant literatures published from January 2014 to June 2020 using the keywords of “resolvin, effect, signaling pathway” in Chinese and English, respectively. Thirty-five articles regarding resolvin and its application were included and analyzed. These databases were also searched using the keywords of “resolving, pulptitis, periapical, periodontitis, dental” in Chinese and English, and 31 articles were included for analyzing the application of resolving in different tissues and diseases, and another 3 articles were further explained of the literature content. RESULTS AND CONCLUSION: In this article, we systematically review the types and effects of resolvin, and detail the role and mechanism of resolvin in inflammatory diseases of the dental pulp, periapical and periodontal tissues. This will so provide the research basis for the preservation and regeneration of vital pulp after its clinical use for dental inflammation. [ABSTRACT FROM AUTHOR]