Statins Do More Than Lower Cholesterol-Depending on What You Eat?

Statins Do More Than Lower Cholesterol - Depending on What You Eat? The cholesterol-independent effects of statins can be explained by the fact that HMG-CoA reductase not only regulates cholesterol synthesis in the liver but also provides all cells of the body with isoprenoids involved in (iso)prenylation of important signaling proteins. Keywords: Editorials; diet; geranylgeranyl pyrophosphate; hydroxymethylglutaryl-CoA reductase inhibitors EN Editorials diet geranylgeranyl pyrophosphate hydroxymethylglutaryl-CoA reductase inhibitors 1793 1796 4 05/06/21 20210504 NES 210504 B Article, see p 1775 b Statins ( -hydroxy -methylglutaryl-coenzyme A [HMG-CoA] reductase inhibitors) belong to the most frequently prescribed classes of drugs worldwide, with rates amounting to 33% of the entire population >60 years of age in Denmark[1] and up to 80% of patients aged 45 to 75 years with established cardiovascular disease in the United States.[2] Statins are competitive inhibitors of HMG-CoA reductase, the rate-limiting enzyme in cholesterol biosynthesis and other isoprenoids (Figure). [Extracted from the article]