塞来昔布防治老年髋部骨折 PTSD 效果及对精神 心理行为影响研究.

Objective To observe the effect of celecoxib on the prevent ion and treatment of PTSD and the influences of psychosocial behavior in elderly patients with hip fractures. Methods A total of 120 elderly orthopedic patients (≥65 years old) with hip fracture from January 2018 to June 2020 in the hospital were collected and randomly divided into group A, group B and group C,40 cases in each group. Group A was high dose experimental group (oral celecoxib 0. 2 g,2 times a day, for 4 weeks); group B was celecoxib low dose experimental group (oral celecoxib 0. 2 g, once a day, for 4 weeks); group C was the blank control group (oral placebo, 2 times a day, for 4 weeks). The levels of Interleukin 1 (IL 1) and IL 6 in each group were measured at 1, 2 and 4 weeks after admission. At week 4 and week 24 after admission, the incidence of post traumatic stress disorder (PTSD), Hamilton Anxiety Scale CHAMA) and Hamilton Depression Scale (HAMD) were used to observe and compare the incidence of post traumatic stress disorder (PTSD) and conduct mental and psychological behavior follow up. Results There was no significant difference in the levels of IL 1 and IL 6 between the three groups in the first and fourth weeks after admission (P>0.05); at the second week after admission, the levels of IL 1 and IL 6 in groups A and B were significantly lower than those in group C, and the differences were statistically significant (P<0.05). In the 4th week of admission, the incidence of PTSD s ymptoms to a certain degree in groups A,B and C was 1 5. 0% (6/40), 22. 5% (9/40) and 20.0% (8/40), respectively, and there was no patients with obvious symptoms of PTSD in three groups. There was no statistically significant difference in the scores of PCLC, HAMA and HAMD a mong the three groups (P>0.05). At the 24th week of admission,the incidence of PTSD symptoms to a certain degree in groups A,B, and C was 0, 0, and 10.0% (4/40), respectively. All three groups had no obvious PTSD symptoms. The total scores and factors scores of PCLC of patients in groups A and B, HAMA, and HAMD were lower than those in group C, and the differences were s tatistically sig nificant (P<0. 05). Conclusion Celecoxib can effectively relieve stress symptoms, anxiety and depression in elderly patients with hip fracture, but there is no relations hip in dose dependent. [ABSTRACT FROM AUTHOR]