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Pyrazolate-based porphyrinic metal-organic frameworks as catechol oxidase mimic enzyme for fluorescent and colorimetric dual-mode detection of dopamine with high sensitivity and specificity.
- Source :
-
Sensors & Actuators B: Chemical . Aug2021, Vol. 341, pN.PAG-N.PAG. 1p. - Publication Year :
- 2021
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Abstract
- [Display omitted] • A dual-signal readout sensor with good sensitivity and selectivity has been developed for dopamine detection. • The study of catechol oxidase mimicking MOF nanozymes has the potential to expand the range of biomimetic MOFs. • The type of modular used in the synthesis process of MOFs can influence the activity of the final enzyme. Enzyme-simulating nanomaterials, with obvious advantages of high activity, stability and cost-effectiveness, can surrogate the complex natural enzymes and catalyze enzyme-like reactions in various harsh applications. Herein, a novel fluorescent and colorimetric dual-readout sensing platform toward dopamine detection based on pyrazolate-based porphyrinic metal-organic frameworks (MOFs) by coordination regulation strategy to improve the performance of catechol oxidase mimic enzyme activity was constructed. Specifically, BA (benzoic acid) or PA (4-Formyl-1(H)-pyrazole) was introduced as auxiliary ligands to regulate the growth mode of pyrazolate-based porphyrinic MOF materials. H 4 TPP (5,10,15,20-Tetra(1 H -pyrazol-4-yl) porphyrin) and auxiliary ligands coordinated with Cu(II), exposing Cu sites with insufficient coordination and enhancing the interaction with oxygen-active species. Benefiting from the binuclear copper center structure and the preferential adsorption of reactants in the self-reinforced interface, a highly sensitive and selective detection method for dopamine based on Cu-TPP(PA) MOF material was proposed under the intervention of H 2 O 2. The feasibility of Cu-TPP(PA) MOF in detecting dopamine in human serum samples and as a paper-based analytical device was investigated. This achievement will expand the applications of MOFs in analytical chemistry and open up a new avenue for the design of highly active and stable nano-enzymes. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 09254005
- Volume :
- 341
- Database :
- Academic Search Index
- Journal :
- Sensors & Actuators B: Chemical
- Publication Type :
- Academic Journal
- Accession number :
- 150291485
- Full Text :
- https://doi.org/10.1016/j.snb.2021.130000