Back to Search
Start Over
Synthesis of hydroxy-α-sanshool.
- Source :
-
Journal of Chemical Research . Mar/Apr2021, Vol. 45 Issue 3/4, p310-314. 5p. - Publication Year :
- 2021
-
Abstract
- Hydroxy-α-sanshool was synthesized in a 13% overall yield through eight steps, which included two Wittig reactions that were used to form the carbon skeleton with ethyl 2-oxoacetate and 2 E,4 E -hexadienal being reacted with the appropriate ylides. Impurities in the processes could easily be separated. Ethyl 6-hydroxy-2Z-hexenoate was converted to its E -isomer with catalysis by I2 and 2E,6Z,8E,10E-dodecatetraenoic acid was crystallized from a solution in 1% ethyl acetate in n -hexane. [ABSTRACT FROM AUTHOR]
- Subjects :
- *WITTIG reaction
*YLIDES
*CATALYSIS
*ETHYL acetate
*SKELETON
Subjects
Details
- Language :
- English
- ISSN :
- 17475198
- Volume :
- 45
- Issue :
- 3/4
- Database :
- Academic Search Index
- Journal :
- Journal of Chemical Research
- Publication Type :
- Academic Journal
- Accession number :
- 150299313
- Full Text :
- https://doi.org/10.1177/1747519820974323