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Synthesis, Crystal Structure and Inhibitory Activities of 2-(N-Tert-Butoxycarbonylamino)Pyridine Derivatives.
- Source :
-
Journal of Chemical Crystallography . Jun2021, Vol. 51 Issue 2, p155-160. 6p. - Publication Year :
- 2021
-
Abstract
- 2-(N-tert-butoxycarbonylamino) pyridine and 2-(N-tert-butoxycarbonylamino)-3-methylpyridine were synthesized in a one-step method using either 2-aminopyridine or 2-amino-3-methyphyridine with tert-butylcarbonyl anhydride as the starting materials. The products were characterized by single-crystal X-ray diffraction, 1H NMR, 13C NMR, and HRMS. The biological activity of the two compounds against five fungi was determined. 2-(N-tert-butoxycarbonylamino) pyridine has more than 50% inhibitory activity against Pyricularia oryzae, Colletotrichum gloeosporioides, and Alternaria alternate. In addition, the inhibitory activity of 2-(N-tert-butoxycarbonylamino)-3-methylpyridine against Alternaria alternate reached 67.69%. Two 2-BOC aminopyridine derivatives were synthesized and structurally characterized by 1H NMR, 13C NMR, HRMS analysis and X-ray crystal diffraction. The inhibitory activity both compounds was studied. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 10741542
- Volume :
- 51
- Issue :
- 2
- Database :
- Academic Search Index
- Journal :
- Journal of Chemical Crystallography
- Publication Type :
- Academic Journal
- Accession number :
- 150341623
- Full Text :
- https://doi.org/10.1007/s10870-020-00833-6