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Base-Catalyzed Intramolecular Defluorination/O-Arylation Reaction for the Synthesis of 3-Fluoro-1,4-oxathiine 4,4-Dioxide.
- Source :
-
Synlett . 2021, Vol. 32 Issue 8, p785-789. 5p. - Publication Year :
- 2021
-
Abstract
- A novel process involving base-catalyzed intramolecular defluorination/O-arylation of readily available α-fluoro-β-one-sulfones was realized and provided a series of 3-fluoro-1,4-oxathiine 4,4-dioxide derivatives in good to excellent yields. Unlike traditional defluorination reactions with stoichiometric base as the deacid reagent, this process is triggered by a catalytic amount of base (TMG: tetramethylguanidine) and molecular sieves serve as both an adsorbent to remove HF acid and an activator to assist C–F bond cleavage. [ABSTRACT FROM AUTHOR]
- Subjects :
- *MOLECULAR sieves
*SCISSION (Chemistry)
*CATALYSIS
Subjects
Details
- Language :
- English
- ISSN :
- 09365214
- Volume :
- 32
- Issue :
- 8
- Database :
- Academic Search Index
- Journal :
- Synlett
- Publication Type :
- Academic Journal
- Accession number :
- 150407446
- Full Text :
- https://doi.org/10.1055/a-1387-8862