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Advances in Lipid-Based Nanoparticles for Cancer Chemoimmunotherapy.
- Source :
-
Pharmaceutics . Apr2021, Vol. 13 Issue 4, p520. 1p. - Publication Year :
- 2021
-
Abstract
- Nanomedicines have shown great potential in cancer therapy; in particular, the combination of chemotherapy and immunotherapy (namely chemoimmunotherapy) that is revolutionizing cancer treatment. Currently, most nanomedicines for chemoimmunotherapy are still in preclinical and clinical trials. Lipid-based nanoparticles, the most widely used nanomedicine platform in cancer therapy, is a promising delivery platform for chemoimmunotherapy. In this review, we introduce the commonly used immunotherapy agents and discuss the opportunities for chemoimmunotherapy mediated by lipid-based nanoparticles. We summarize the clinical trials involving lipid-based nanoparticles for chemoimmunotherapy. We also highlight different chemoimmunotherapy strategies based on lipid-based nanoparticles such as liposomes, nanodiscs, and lipid-based hybrid nanoparticles in preclinical research. Finally, we discuss the challenges that have hindered the clinical translation of lipid-based nanoparticles for chemoimmunotherapy, and their future perspectives. [ABSTRACT FROM AUTHOR]
- Subjects :
- *LIPOSOMES
*NANOPARTICLES
*COMBINATION drug therapy
*CANCER treatment
*NANOMEDICINE
Subjects
Details
- Language :
- English
- ISSN :
- 19994923
- Volume :
- 13
- Issue :
- 4
- Database :
- Academic Search Index
- Journal :
- Pharmaceutics
- Publication Type :
- Academic Journal
- Accession number :
- 150434221
- Full Text :
- https://doi.org/10.3390/pharmaceutics13040520