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Nucleosidyl-O-Methylphosphonates: A Pool of Monomers for Modified Oligonucleotides.
- Source :
-
Nucleosides, Nucleotides & Nucleic Acids . Nov2004, Vol. 23 Issue 11, p1683-1705. 23p. 6 Diagrams, 13 Charts. - Publication Year :
- 2004
-
Abstract
- An unique set of 5′-O- and 3′-O-phosphonomethyl derivatives of four natural 2′-deoxyribonucleosides, 1-(2-deoxy-β-D-threo-pentofuranosyl)thymine, 5′-O- and 2′-O-phosphonomethyl derivatives of 1-(3-deoxy-β-D-erythro-pentofuranosyl)thymine, and 1-(3-deoxy-β-D-threo-pentofuranosyl)thymine has been synthesized as a pool of monomers for the synthesis of modified oligonucleotides. The phosphonate moiety was protected with 4-methoxy-1-oxido-2-pyridylmethyl ester group, serving also as an intramolecular catalyst in the coupling step. [ABSTRACT FROM AUTHOR]
- Subjects :
- *OLIGONUCLEOTIDES
*NUCLEOTIDES
*PHOSPHONATES
*MONOMERS
Subjects
Details
- Language :
- English
- ISSN :
- 15257770
- Volume :
- 23
- Issue :
- 11
- Database :
- Academic Search Index
- Journal :
- Nucleosides, Nucleotides & Nucleic Acids
- Publication Type :
- Academic Journal
- Accession number :
- 15043465
- Full Text :
- https://doi.org/10.1081/NCN-200033912