利伐沙班与低分子肝素对老年AECOPD患者症状缓解、血气分析指标及凝血功能的影响.

Objective: To investigate the effects of rivaroxaban and low molecular weight heparin on the symptom relief, blood gas analysis indexes and coagulation function in elderly patients with acute exacerbation of chronic obstructive pulmonary disease（AECOPD）. Methods: A total of 72 elderly patients with AECOPD admitted to our hospital from August 2016 to November 2019 were selected, and were randomly divided into control group（n=36, low molecular weight heparin treatment） and study group（n=36,rivaroxaban treatment） by lottery. The efficacy, symptom relief, blood gas analysis index and coagulation function of the two groups were compared, and adverse reactions during the treatment were recorded. Results: The total effective rate of the study group 10 days after treatment was higher than the control group（P<0.05）. There were no significant differences in the relief time of cough, sputum, fever and dyspnea between the two groups（P>0.05）. 10 days after treatment, the oxygen partial pressure（PaO2）, oxygen saturation（SaO2） of the two groups increased, while the partial pressure of carbon dioxide（PaCO2） of the two groups decreased（P<0.05）. 10 days after treatment,PaO2 and SaO2 of the study group were higher than the control group, while PaCO2 was lower than those of the control group（P<0.05）.10 days after treatment, fibrinogen（Fib） of the two groups increased, D-Dimer（D-D）, activated partial thromboplastin time（APTT）,plasma prothrombin time（PT） and thrombin time（TT） decreased（P<0.05）. 10 days after treatment, D-D of the study group was lower than the control group（P<0.05）. There were no significant differences between Fib, APTT, TT and PT of the two groups（P>0.05）. There was no significant difference in the incidence of adverse reactions between the two groups（P>0.05）. Conclusion: Elderly patients with AECOPD treated with rivaroxaban and low molecular weight heparin can improved their clinical symptoms and showed better safety, but those treated with rivaroxaban had better efficacy, and better improvement in blood gas analysis indicators and coagulation function. [ABSTRACT FROM AUTHOR]