纤维调节素抑制脂多糖诱导性动物牙周炎的实验分析.

Objective: To explore and analysis the effect and mechanism of fibronectin on inhibiting lipopolysaccharide-induced periodontitis in rats. Methods: A total of 36 healthy female Wistar rats were equally divided into three groups-control group, periodontitis group and fibronectin group. The control group was given normal feeding without any intervention; the fibronectin group was given 80 mg/kg d of fibronectin every day for 2 weeks, and the periodontitis group was given an equal volume of normal saline gavage treatment for 4 weeks. Results: At the 2nd and 4th week of treatment, the gingival index, probing depth, and alveolar bone resorption values of the periodontitis group and the fibronectin group were higher than those of the control group (P<0.05), and the fibronectin group was lower than the periodontitis group (P<0.05); the serum osteocalcin (OCN) values of the periodontitis group and fibronectin group were higher than those of the control group (P<0.05), and alkaline phosphatase (ALP) values were lower than those of the control group (P<0.05), there were statistically significant differences between the periodontitis group and the fibronectin group (P<0.05); the relative expression level of Src Homology Phosphotyrosyl Phosphatase 2 (SHP-2) of the periodontitis group and the fibronectin group were higher than that of the control group (P<0.05), the fibronectin group was lower than the periodontitis group (P<0.05). Conclusions: Fibromodulin can inhibit the progression of lipopolysaccharide-induced periodontitis in rats, inhibit the expression of OCN and SHP-2 protein, and promote the expression of ALP, thereby improving the related symptoms of periodontitis rats. [ABSTRACT FROM AUTHOR]