Preclinical Evaluation of Lipid-Based Nanosystems.

The use of lipid-based nanosystems, including lipid nanoparticles (solid lipid nanoparticles - SLN, and nanostructured lipid carriers - NLC), nanoemulsions, and liposomes, among others, is widespread. 32806740 12 Almasri R., Joyce P., Schultz H.B., Thomas N., Bremmell K.E., Prestidge C.A. Porous Nanostructure, Lipid Composition, and Degree of Drug Supersaturation Modulate In Vitro Fenofibrate Solubilization in Silica-Lipid Hybrids. In addition, the results of the ex vivo permeation studies and in vivo pharmacokinetics studies showed a greater efficacy of the optimized clarithromycin-loaded SLN compared to a drug solution, suggesting that the developed formulation may be a viable drug delivery approach for treating endophthalmitis. C.A. Prestidge et al. [[12]] studied the impact of the main characteristics of a nanostructured matrix obtained by silica-lipid hybrids in the construction of optimized solid-state lipid-based formulations for the oral delivery of poorly water-soluble drugs. [Extracted from the article]