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Solid-phase synthesis of fluorescent analogues of Park's nucleotide, lipid I and lipid II.
- Source :
-
Tetrahedron Letters: International Organ for the Rapid Publication of Preliminary Communications in Organic Chemistry . Jun2021, Vol. 73, pN.PAG-N.PAG. 1p. - Publication Year :
- 2021
-
Abstract
- [Display omitted] • Solid-phase synthesis of fluorescent probe of Park's nucleotide, lipid I and lipid II. • Introduction of fluorescent groups at the late stage of synthesis and sigle HPLC purification. • Potential to modular synthesis of functional analogues of Park's nucleotide, lipid I and lipid II. Solid-phase modular synthesis of fluorescent analogues of Park's nucleotide, lipid I and II, is described. The Fmoc protected lysine side chain of resin-bound intermediates were selectively modified by various fluorescent groups. This is the first example of solid-phase synthesis of these compounds. This synthetic strategy allows the preparation of various fluorescent probes for investigating the mechanisms of bacterial cell-wall biosynthesis. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00404039
- Volume :
- 73
- Database :
- Academic Search Index
- Journal :
- Tetrahedron Letters: International Organ for the Rapid Publication of Preliminary Communications in Organic Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 150613760
- Full Text :
- https://doi.org/10.1016/j.tetlet.2021.153101