Solid-phase synthesis of fluorescent analogues of Park's nucleotide, lipid I and lipid II.

[Display omitted] • Solid-phase synthesis of fluorescent probe of Park's nucleotide, lipid I and lipid II. • Introduction of fluorescent groups at the late stage of synthesis and sigle HPLC purification. • Potential to modular synthesis of functional analogues of Park's nucleotide, lipid I and lipid II. Solid-phase modular synthesis of fluorescent analogues of Park's nucleotide, lipid I and II, is described. The Fmoc protected lysine side chain of resin-bound intermediates were selectively modified by various fluorescent groups. This is the first example of solid-phase synthesis of these compounds. This synthetic strategy allows the preparation of various fluorescent probes for investigating the mechanisms of bacterial cell-wall biosynthesis. [ABSTRACT FROM AUTHOR]