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AgI‐Catalyzed Reaction of Enol Diazoacetates and Imino Ethers: Synthesis of Highly Functionalized Pyrroles.
- Source :
-
Angewandte Chemie . 6/7/2021, Vol. 133 Issue 24, p13506-13512. 7p. - Publication Year :
- 2021
-
Abstract
- An unprecedented AgI‐catalyzed efficient method for the coupling of imino ethers and enol diazoacetates through a [3+2]‐cycloaddition/C−O bond cleavage/[1,5]‐proton transfer cascade process is reported. The general class of imino ethers that includes oxazolines, benzoxazoles and benzimidates are applicable substrates for these reactions that provide direct access to fully substituted pyrroles with uniformly high chemo‐ and regioselectivity. High variability in substitution at the pyrrole 2‐, 5‐ and N‐positions characterizes this methodology that also presents an entry point for further pyrrole diversification via facile modification of resulting N‐functional pyrroles. [ABSTRACT FROM AUTHOR]
- Subjects :
- *ETHER synthesis
*PYRROLES
*ENOL ethers
*BENZOXAZOLES
*DIPYRROMETHANES
*ETHERS
Subjects
Details
- Language :
- English
- ISSN :
- 00448249
- Volume :
- 133
- Issue :
- 24
- Database :
- Academic Search Index
- Journal :
- Angewandte Chemie
- Publication Type :
- Academic Journal
- Accession number :
- 150674677
- Full Text :
- https://doi.org/10.1002/ange.202101641