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Di-ortho-C[sbnd]H arylation of phenylalanine: A bimetallic interaction between Pd(IV)-Ag(I).
- Source :
-
Tetrahedron Letters: International Organ for the Rapid Publication of Preliminary Communications in Organic Chemistry . Jun2021, Vol. 74, pN.PAG-N.PAG. 1p. - Publication Year :
- 2021
-
Abstract
- [Display omitted] • Direct ortho -diarylation via MIA-mediated Pd-catalyzed C-H functionalization. • Di- ortho -arylated phenylalanine derivatives with good to high efficiency. • Localized orbital between Pd(IV) and Ag 2 CO 3 favored the reductive elimination step. The direct di -ortho -arylation of substituted phenylalanines has been accomplished via methoxyiminoacyl (MIA)-mediated Pd-catalyzed C H functionalization. A diverse array of phenylalanine substrates is amenable to this protocol, providing di -ortho -arylated phenylalanine derivatives with good to high efficiency. Computational results revealed that a bimetallic interaction between Pd(IV)-Ag(I) was formed through the localized orbital, which obviously favored the reductive elimination step of the arylation process. [ABSTRACT FROM AUTHOR]
- Subjects :
- *ARYLATION
*PHENYLALANINE
*CARBON dioxide
*PALLADIUM catalysts
Subjects
Details
- Language :
- English
- ISSN :
- 00404039
- Volume :
- 74
- Database :
- Academic Search Index
- Journal :
- Tetrahedron Letters: International Organ for the Rapid Publication of Preliminary Communications in Organic Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 150749495
- Full Text :
- https://doi.org/10.1016/j.tetlet.2021.153158