Di-ortho-C[sbnd]H arylation of phenylalanine: A bimetallic interaction between Pd(IV)-Ag(I).

[Display omitted] • Direct ortho -diarylation via MIA-mediated Pd-catalyzed C-H functionalization. • Di- ortho -arylated phenylalanine derivatives with good to high efficiency. • Localized orbital between Pd(IV) and Ag 2 CO 3 favored the reductive elimination step. The direct di -ortho -arylation of substituted phenylalanines has been accomplished via methoxyiminoacyl (MIA)-mediated Pd-catalyzed C H functionalization. A diverse array of phenylalanine substrates is amenable to this protocol, providing di -ortho -arylated phenylalanine derivatives with good to high efficiency. Computational results revealed that a bimetallic interaction between Pd(IV)-Ag(I) was formed through the localized orbital, which obviously favored the reductive elimination step of the arylation process. [ABSTRACT FROM AUTHOR]