Synthetic studies towards (±)-isopalhinine A: Preparation of the bicyclic core via Nazarov cyclization.

Authors :: Nakhla, Mina C.
Cook, Christopher D.
Wood, John L.
Source :: Tetrahedron Letters: International Organ for the Rapid Publication of Preliminary Communications in Organic Chemistry. Jun2021, Vol. 74, pN.PAG-N.PAG. 1p.
Publication Year :: 2021
Abstract: [Display omitted] • Natural product inspires the application of allene ether Nazarov Chemistry. • Torquoselectivity guides the stereochemical course in allene ether Nazarov Reaction. • Palladium precatalyst greatly improves efficiency in an enol triflate to ene-amide conversion. This manuscript describes progress towards the total synthesis of (±)-isopalhinine A wherein an allene ether Nazarov cyclization gives rise to the bicyclic core. [ABSTRACT FROM AUTHOR]

Subjects :: *RING formation (Chemistry)
*ALLENE
*NATURAL products
*PALLADIUM

Language :: English
ISSN :: 00404039
Volume :: 74
Database :: Academic Search Index
Journal :: Tetrahedron Letters: International Organ for the Rapid Publication of Preliminary Communications in Organic Chemistry
Publication Type :: Academic Journal
Accession number :: 150749504
Full Text :: https://doi.org/10.1016/j.tetlet.2021.153177

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