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Therapeutic and prognostic role of vitamin D for COVID-19 infection: A systematic review and meta-analysis of 43 observational studies.
- Source :
-
Journal of Steroid Biochemistry & Molecular Biology . Jul2021, Vol. 211, pN.PAG-N.PAG. 1p. - Publication Year :
- 2021
-
Abstract
- • Vitamin D modulates the systemic inflammatory response through interaction with immune system. • We systematically reviewed studies about vitamin D3 and risk and mortality for COVID-19 infection. • Reduced vitamin D values resulted in a higher infection risk, mortality and severity COVID-19 infection. Vitamin D modulates the systemic inflammatory response through interaction with immune system. As such, it has a possible protective role against the risk of respiratory tract infections and other diseases. It may be useful in particular, during COVID-19 pandemic. PubMed, the Cochrane Library, and EMBASE were searched from inception until January 31, 2021, for observational or clinical studies reporting the prognosis (and therapeutic effect) of COVID-19 infection in patients with deficient vitamin D levels. The infection rate, severity, and death from COVID-19 infection were pooled to provide an odds ratio with a 95 % confidence interval (OR 95 % CI). An OR > 1 was associated with the worst outcome in deficient compared with nondeficient patients. We assessed the association between vitamin D and risk, severity, and mortality for COVID-19 infection, through a review of 43 observational studies. Among subjects with deficient vitamin D values, risk of COVID-19 infection was higher compared to those with replete values (OR = 1.26; 95 % CI, 1.19–1.34; P <.01). Vitamin D deficiency was also associated with worse severity and higher mortality than in nondeficient patients (OR = 2.6; 95 % CI, 1.84–3.67; P <.01 and OR = 1.22; 95 % CI, 1.04–1.43; P <.01, respectively). Reduced vitamin D values resulted in a higher infection risk, mortality and severity COVID-19 infection. Supplementation may be considered as preventive and therapeutic measure. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 09600760
- Volume :
- 211
- Database :
- Academic Search Index
- Journal :
- Journal of Steroid Biochemistry & Molecular Biology
- Publication Type :
- Academic Journal
- Accession number :
- 150876948
- Full Text :
- https://doi.org/10.1016/j.jsbmb.2021.105883