Performance of 2-Hydroxy-1-Naphthaldehyde-2-Amino Thiazole as a Highly Selective Turn-on Fluorescent Chemosensor for Al(III) Ions Detection and Biological Applications.

The thiazole based Schiff base 2-hydroxy-1-naphthaldehyde-2-amino thiazole (receptor1) was synthesized through a single step process and characterized by spectroscopic and analytical techniques. The cation detecting ability of the receptor1 was explored by fluorescent spectroscopic methods. The receptor1 has recognized Al3+ ions by a turn-on process over a panel of other potentially competing metal ions. The binding constant of receptor1 with Al3+ was found to be 8.27 × 103 M−1. Computational studies Density Functional Theory (DFT) and Time-dependent Density Functional Theory (TD-DFT) were performed to provide detailed information on electronic states and photophysical property of receptor1 and receptor1-Al3+ ions. MTT (3-(4,5-dimethyl thiazole-2-yl)-2,5-diphenyl tetrazolium bromide) assay and bioimaging applications were made on breast carcinoma cells in humans. [ABSTRACT FROM AUTHOR]