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Rapid determination of benzophenone derivatives in cereals using FaPEx coupled with ultraehigh-performance liquid chromatographyetandem mass spectrometry.
- Source :
-
Journal of Food & Drug Analysis . 2021, Vol. 29 Issue 2, p287-302. 16p. - Publication Year :
- 2021
-
Abstract
- A robust and sensitive analytical method was developed and validated for the simultaneous analysis of the levels of 10 benzophenone derivatives (BPs; BP, BP-1, BP-2, BP-3, BP-8, 2-hydroxybenzophenone [2-OHBP], 4-hydroxybenzophenone [4-OHBP], 4-methylbenzophenone [4-MBP], methyl-2-benzoylbenzoate [M2BB], and 4-benzoylbiphenyl [PBZ]) in 54 breakfast cereal samples. A fast pesticide extraction (FaPEx) technique coupled with isotope-labeled internal standards ultraehigh-performance liquid chromatographyetandem mass spectrometry was employed. The developed method exhibited satisfactory linearity (R²> 0.998), high precision (intraday and interday relative standard deviations in the ranges of 1.4%e20.8% and 3.2%e23.9%, respectively), and a limit of detection ranging from 0.001 to 0.122 ng/g. BP and 4-MBP were detected in all samples, BP-3 was detected in >59% of the samples, M2BB was detected in 14% of the samples, and 4-OHBP was detected in 7% of the samples. The mean level (range) of BP was significantly higher in corn flakes [146.9 (25.3e1083.8) ng/g] than in oatmeal [22.8 (14.2e67.5) ng/g], and it contributed the most to the overall levels of the BPs, followed by 4-MBP. When the samples were stratified according to their packaging material, the mean level of BP was significantly higher in corn flake samples with plastic packaging (251.9 ng/g) than in corn flake and oatmeal samples with laminated aluminum foil packaging. Two samples of six-grain muesli contained remarkably high levels of BP (1084 and 1055 ng/g); both were nonorganic samples packaged in a polylactide bag. Future studies must examine the possible risks that these contaminants pose to human health. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 10219498
- Volume :
- 29
- Issue :
- 2
- Database :
- Academic Search Index
- Journal :
- Journal of Food & Drug Analysis
- Publication Type :
- Academic Journal
- Accession number :
- 150942399
- Full Text :
- https://doi.org/10.38212/2224-6614.3353