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An Efficient Strategy for the Synthesis of Naphtho[2,3- b ][1,6]naphthyridines Promoted by Acetic Acid.
- Source :
-
Synlett . 2021, Vol. 32 Issue 11, p1117-1122. 6p. - Publication Year :
- 2021
-
Abstract
- A three-component domino reaction for the synthesis of naphtho[2,3- b ][1,6]naphthyridine derivatives has been established. Such strategy exhibited excellent substrate scope including various enaminones and aldehydes that afforded a series of multifunctionalized naphtho[2,3- b ][1,6]naphthyridine derivatives with 70–86% yields. The advantages of bond-forming efficiency, accessibility of starting materials, and water as sole byproducts provide invaluable access to biological 1,6-naphthyridines. [ABSTRACT FROM AUTHOR]
- Subjects :
- *NAPHTHYRIDINES
*ALDEHYDES
*WASTE products
Subjects
Details
- Language :
- English
- ISSN :
- 09365214
- Volume :
- 32
- Issue :
- 11
- Database :
- Academic Search Index
- Journal :
- Synlett
- Publication Type :
- Academic Journal
- Accession number :
- 150965888
- Full Text :
- https://doi.org/10.1055/a-1479-4420