An Efficient Strategy for the Synthesis of Naphtho[2,3- b ][1,6]naphthyridines Promoted by Acetic Acid.

A three-component domino reaction for the synthesis of naphtho[2,3- b ][1,6]naphthyridine derivatives has been established. Such strategy exhibited excellent substrate scope including various enaminones and aldehydes that afforded a series of multifunctionalized naphtho[2,3- b ][1,6]naphthyridine derivatives with 70–86% yields. The advantages of bond-forming efficiency, accessibility of starting materials, and water as sole byproducts provide invaluable access to biological 1,6-naphthyridines. [ABSTRACT FROM AUTHOR]