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Cesium Carbonate Mediated Cyclization of Oxotryptamines with Allenoates: An Approach to Spiro[azepane-4,3′-indol]-2′(1′ H)-ones.
- Source :
-
Synlett . 2021, Vol. 32 Issue 11, p1093-1097. 5p. - Publication Year :
- 2021
-
Abstract
- A new method was developed for the synthesis of spiro[azepane-4,3′-indol]-2′(1′ H)-ones in yields of up to 96% with a broad substrate scope by using oxotryptamines as dual-nucleophilic reagents to react with allenoates in the presence of cesium carbonate under mild conditions. In accord with previous works and a deprotonation-tracing experiment, a plausible reaction mechanism is proposed. [ABSTRACT FROM AUTHOR]
- Subjects :
- *CESIUM
*CARBONATES
*RING formation (Chemistry)
*SPIRO compounds
Subjects
Details
- Language :
- English
- ISSN :
- 09365214
- Volume :
- 32
- Issue :
- 11
- Database :
- Academic Search Index
- Journal :
- Synlett
- Publication Type :
- Academic Journal
- Accession number :
- 150965896
- Full Text :
- https://doi.org/10.1055/a-1507-4275