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Fabrication of epirubicin loaded core/shell electrospun fibers with effective transdermal sustained-release properties.
- Source :
-
Materials Letters . Sep2021, Vol. 299, pN.PAG-N.PAG. 1p. - Publication Year :
- 2021
-
Abstract
- • Epirubicin-loaded polyacrylonitrile electrospun nanofibers were fabricated. • The electrospun emulsion was prepared by the low energy magnetic stirring method. • Tween 80 contributed to the formation of the core/shell structure of the fibers. • The in vitro drug release followed the Korsmeyer-Peppas equation. • The prepared nanofibers had effective transdermal sustained-release behavior. Epirubicin-loaded polyacrylonitrile nanofibers were fabricated by the low energy water-in-oil emulsion electrospinning technique using the drug solution as the aqueous phase and the N, N- dimethylformamide solution of polyacrylonitrile as the oil phase. Tween 80 as a surfactant was applied to contribute to the formation of the core/shell structure of fibers. The in vitro drug release of these drug-loaded nanofibers obeyed the Korsmeyer-Peppas equation, by exhibiting a good sustained-release performance. In addition, in vitro permeation studies across artificial human skin showed that the prepared nanofibers had effective transdermal sustained-release behavior and the optimum drug cumulative amounts reached 61% in 24 h. The nanofiber membrances exhibited good flexibility and high tensile strength (7.93 MPa), which favors their potential application in transdermal drug delivery. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 0167577X
- Volume :
- 299
- Database :
- Academic Search Index
- Journal :
- Materials Letters
- Publication Type :
- Academic Journal
- Accession number :
- 150968879
- Full Text :
- https://doi.org/10.1016/j.matlet.2021.130117