Back to Search
Start Over
Thermosensitive Vesicles from Chemically Encoded Lipid‐Grafted Elastin‐like Polypeptides.
- Source :
-
Angewandte Chemie International Edition . 6/25/2021, Vol. 60 Issue 27, p15036-15040. 5p. - Publication Year :
- 2021
-
Abstract
- Biomimetic design to afford smart functional biomaterials with exquisite properties represents synthetic challenges and provides unique perspectives. In this context, elastin‐like polypeptides (ELPs) recently became highly attractive building blocks in the development of lipoprotein‐based membranes. In addition to the bioengineered post‐translational modifications of genetically encoded recombinant ELPs developed so far, we report here a simple and versatile method to design biohybrid brush‐like lipid‐grafted‐ELPs using chemical post‐modification reactions. We have explored a combination of methionine alkylation and click chemistry to create a new class of hybrid lipoprotein mimics. Our design allowed the formation of biomimetic vesicles with controlled permeability, correlated to the temperature‐responsiveness of ELPs. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 14337851
- Volume :
- 60
- Issue :
- 27
- Database :
- Academic Search Index
- Journal :
- Angewandte Chemie International Edition
- Publication Type :
- Academic Journal
- Accession number :
- 151003062
- Full Text :
- https://doi.org/10.1002/anie.202102807