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Ketene 3‐Component Staudinger Reaction (K‐3CSR) to β‐Lactams: A New Entry in the Class of Photoinduced Multicomponent Reactions.

Authors :
Minuto, Federica
Lambruschini, Chiara
Basso, Andrea
Source :
European Journal of Organic Chemistry. 6/14/2021, Vol. 2021 Issue 22, p3270-3273. 4p.
Publication Year :
2021

Abstract

The Staudinger synthesis of β‐lactams from imines and ketenes has been conducted photochemically only in very limited cases. Recent advances in the visible light mediated Wolff rearrangement of diazoketones allowed us to perform, for the first time, a 3‐component Staudinger reaction, by mixing aldehydes, amines and diazoketones in the dark and switching the light on after imine formation. The new photoinduced reaction parallels the classic methods in terms of efficiency/selectivity and adds to the existing multicomponent approaches for the preparation of combinatorial libraries of compounds. A thorough optimization of the reaction conditions was performed both for the classic two component reaction and for the novel three component version of the photoinduced Staudinger reaction. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
1434193X
Volume :
2021
Issue :
22
Database :
Academic Search Index
Journal :
European Journal of Organic Chemistry
Publication Type :
Academic Journal
Accession number :
151023019
Full Text :
https://doi.org/10.1002/ejoc.202100577