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LncRNA HOTAIR regulates the expression of E-cadherin to affect nasopharyngeal carcinoma progression by recruiting histone methylase EZH2 to mediate H3K27 trimethylation.
- Source :
-
Genomics . Jul2021, Vol. 113 Issue 4, p2276-2289. 14p. - Publication Year :
- 2021
-
Abstract
- There has been increasing evidence for the function of long non-coding RNA (lncRNA) in nasopharyngeal carcinoma (NPC). We aim to delve into the position of lncRNA HOX antisense intergenic RNA (HOTAIR), together with enhancer of zeste homolog 2 (EZH2), E-cadherin and trimethylation of lysine 27 on histone H3 (H3K27me3) in NPC. HOTAIR, EZH2, and E-cadherin expression in NPC tissues and cells were tested. NPC cell biological functions were examined through gain-of and loss-of function assays. The mechanism of lncRNA HOTAIR/E-cadherin/EZH2/H3K27 axis in NPC was decoded. LncRNA HOTAIR and EZH2 were highly expressed in NPC, and E-cadherin was lowly expressed. Down-regulation of HOTAIR or EZH2 inhibited NPC cell progression and tumor growth. HOTAIR recruited histone methylase EZH2 to mediate trimethylation of H3K27 and regulated E-cadherin expression. HOTAIR inhibits E-cadherin by stimulating the trimethylation of H3K27 to promote NPC cell progression through recruiting histone methylase EZH2. • HOTAIR and EZH2 are highly expressed and E-cadherin is poorly expressed in NPC. • Upregulation of HOTAIR or EZH2 induces NPC cell progression and tumor growth. • Down-regulation of HOTAIR or EZH2 inhibits NPC cell progression and tumor growth. • Increased EZH2 compensates HOTAIR silencing in NPC growth. • The study provides a novel reference for treatment of NPC. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 08887543
- Volume :
- 113
- Issue :
- 4
- Database :
- Academic Search Index
- Journal :
- Genomics
- Publication Type :
- Academic Journal
- Accession number :
- 151173337
- Full Text :
- https://doi.org/10.1016/j.ygeno.2021.03.036