Back to Search
Start Over
The effects of topical application of phytonadione, retinol and vitamins C and E on infraorbital dark circles and wrinkles of the lower eyelids.
- Source :
-
Journal of Cosmetic Dermatology . Apr2004, Vol. 3 Issue 2, p73-75. 3p. - Publication Year :
- 2004
-
Abstract
- Infraorbital dark circles and wrinkles of the lower eyelids are a cosmetic problem, especially with age.To determine whether a gel containing 2% phytonadione, 0.1% retinol and 0.1% vitamins C and E is effective in reducing dark under-eye circles and wrinkles of the lower eyelids in healthy Japanese adults.Fifty-seven adult Japanese volunteers with dark under-eye circles and wrinkles were enrolled in an open label study. The gel formulation was applied twice daily to the lower eyelid site for 8 weeks. Haemostasis, pigmentation and wrinkles were evaluated by a physician and by the patients themselves, using a digital camera and a visual analogue scale respectively, after 4 and 8 weeks of treatment.Topical application of the gel decreased not only haemostasis but also wrinkles after 8 weeks of treatment. Of 57 patients, 27 (47%) had reductions in haemostasis. Wrinkles were also decreased in some patients. However, pigmentation was not clearly removed by this gel.Topical application of the gel containing 2% phytonadione, 0.1% retinol, 0.1% vitamin C and 0.1% vitamin E was fairly or moderately effective in reducing dark under-eye circles, especially in cases of haemostasis, over a short treatment period in healthy Japanese adults. This treatment also slightly decreased wrinkles. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 14732130
- Volume :
- 3
- Issue :
- 2
- Database :
- Academic Search Index
- Journal :
- Journal of Cosmetic Dermatology
- Publication Type :
- Academic Journal
- Accession number :
- 15123389
- Full Text :
- https://doi.org/10.1111/j.1473-2130.2004.00070.x