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Weight‐adapted fixed‐dose combined adult antiretroviral tablets for HIV‐infected children.
- Source :
-
Journal of Clinical Pharmacy & Therapeutics . Aug2021, Vol. 46 Issue 4, p867-871. 5p. - Publication Year :
- 2021
-
Abstract
- What is known and objective: Therapeutic alternatives to simplify antiretroviral therapy (ART) in HIV‐infected children are needed. We report our experience with abacavir(ABC)/lamivudine(3TC) individualized dose compounded capsules (IDCC). Comment: We present a prospective case series of HIV‐infected children who did not weigh enough to receive the adult fixed‐dose combination including ABC/3TC 600mg/300mg, and were treated with weight‐adapted ABC/3TC IDCC in Barcelona, Spain. Thirteen patients (12 girls) received ABC/3TC IDCC for a median(IQR) time of 30(17‐54) months. No significant changes were observed in CD4 cell counts, weight or height z‐scores over time. Suppression of viral replication was maintained in 7 patients with undetectable viremia at baseline. Another 5 patients achieved viral suppression with ABC/3TC IDCC‐based ART, while one non‐adherent girl did not. No adverse events related to ABC/3TC IDCC were observed. What is new and conclusion: Despite small numbers, the long‐term use of ABC/3TC IDCC was feasible, safe, and effective in the treatment of HIV‐infected children. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 02694727
- Volume :
- 46
- Issue :
- 4
- Database :
- Academic Search Index
- Journal :
- Journal of Clinical Pharmacy & Therapeutics
- Publication Type :
- Academic Journal
- Accession number :
- 151285509
- Full Text :
- https://doi.org/10.1111/jcpt.13341