Alveolar ridge preservation with fibroblast growth factor‐2 modified acellular dermal matrix membrane and a bovine‐derived xenograft: An experimental in vivo study.

Objective: To investigate the effect of a bone substitute material combined with fibroblast growth factor‐2 (FGF‐2) loaded barrier membrane on the preservation of alveolar ridge after tooth extraction. Material and methods: Four dogs were included. Six extraction sockets of each animal received the 3 treatments and were randomly divided into three groups. Group A: negative control; Group B: bovine xenografts + membrane; and Group C: bovine xenografts + FGF‐2‐loaded membrane. CBCT and histological analysis were performed to evaluate changes in the width and height of alveolar ridges and extraction socket bone healing 8 weeks post‐extraction. Results: CBCT showed that the alveolar bone in Group A was significantly thinner than that in Group B and Group C at 1 and 3 mm apically from the alveolar crest. The alveolar width at 1 mm in Group C (60.99 ± 15.36%) was significantly thicker than that in Group B (39.75 ± 30.18%). Histomorphmetrical measurements showed that the buccal alveolar width at 1 mm was significantly thicker in Groups B and C than in Group A. Additionally, buccal bone height and lingual bone width at 1 mm in Group C (87.06 ± 10.34%, 89.09 ± 10.56%) were significantly greater than in Group A (53.48 ± 23.94%, 82.72 ± 12.59%). Conclusion: The present findings indicate that application of bovine bone combined with barrier membrane with or without FGF‐2 over tooth sockets can effectively reduce ridge absorption, especially in terms of ridge width and FGF‐2 modified membrane seems to improve the outcomes obtained with membrane alone. [ABSTRACT FROM AUTHOR]