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MHC Class I Deficiency in Solid Tumors and Therapeutic Strategies to Overcome It.
- Source :
-
International Journal of Molecular Sciences . Jul2021, Vol. 22 Issue 13, p6741-6741. 1p. - Publication Year :
- 2021
-
Abstract
- It is now well accepted that the immune system can control cancer growth. However, tumors escape immune-mediated control through multiple mechanisms and the downregulation or loss of major histocompatibility class (MHC)-I molecules is a common immune escape mechanism in many cancers. MHC-I molecules present antigenic peptides to cytotoxic T cells, and MHC-I loss can render tumor cells invisible to the immune system. In this review, we examine the dysregulation of MHC-I expression in cancer, explore the nature of MHC-I-bound antigenic peptides recognized by immune cells, and discuss therapeutic strategies that can be used to overcome MHC-I deficiency in solid tumors, with a focus on the role of natural killer (NK) cells and CD4 T cells. [ABSTRACT FROM AUTHOR]
- Subjects :
- *CYTOTOXIC T cells
*TUMOR growth
*T cells
*IMMUNE system
*IMMUNE checkpoint proteins
Subjects
Details
- Language :
- English
- ISSN :
- 16616596
- Volume :
- 22
- Issue :
- 13
- Database :
- Academic Search Index
- Journal :
- International Journal of Molecular Sciences
- Publication Type :
- Academic Journal
- Accession number :
- 151319417
- Full Text :
- https://doi.org/10.3390/ijms22136741