Sublimation thermodynamics of antifungal drugs: Tioconazole, miconazole and climbazole.

The temperature dependence of the saturated vapour pressure of the antifungal drugs – tioconazole (TCZ), miconazole (MCZ) and climbazole (CLZ) – was determined by the inert gas carrier transfer method. The standard molar enthalpies of sublimation at T = 298.15 K calculated from these data were 117.2 ± 0.5 kJ·mol-1 for TCZ ± 0.9, 106.2 ± 1.0 kJ·mol-1 for MCZ and 113.3 kJ·mol-1for CLZ. The vaporization and sublimation enthalpies of the compounds were found by the Langmuir and Clausius-Clapeyron equations without determining the vapour pressures of the drugs. Sublimation enthalpies derived by both these methods were in good agreement. It was shown that it was possible to estimate the thermodynamic sublimation functions by applying the space clusterization approach to the studied and structurally related compounds. In addition, the temperature and enthalpy of fusion of the compounds were measured by differential scanning calorimetry. [ABSTRACT FROM AUTHOR]