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Endosomal‐lysosomal dysfunctions in Alzheimer's disease: Pathogenesis and therapeutic interventions.
- Source :
-
Metabolic Brain Disease . Aug2021, Vol. 36 Issue 6, p1087-1100. 14p. - Publication Year :
- 2021
-
Abstract
- The endosomal-lysosomal system mediates the process of protein degradation through endocytic pathway. This system consists of early endosomes, late endosomes, recycling endosomes and lysosomes. Each component in the endosomal-lysosomal system plays individual crucial role and they work concordantly to ensure protein degradation can be carried out functionally. Dysregulation in the endosomal-lysosomal system can contribute to the pathogenesis of neurodegenerative diseases such as Alzheimer's disease (AD). In AD endosomal-lysosomal abnormalities are the earliest pathological features to note and hence it is important to understand the involvement of endosomal-lysosomal dysfunction in the pathogenesis of AD. In-depth understanding of this dysfunction can allow development of new therapeutic intervention to prevent and treat AD. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 08857490
- Volume :
- 36
- Issue :
- 6
- Database :
- Academic Search Index
- Journal :
- Metabolic Brain Disease
- Publication Type :
- Academic Journal
- Accession number :
- 151351456
- Full Text :
- https://doi.org/10.1007/s11011-021-00737-0