基于L-丙氨酰谷氨酰胺的肠外营养在ICU重症颅脑损伤的应用.

Objective: To explore the application values of L-alanylglutamine-based parenteral nutrition in the Intensive Care Unit (ICU) of severe head injury. Methods: A total of 540 patients with severe head injury, who were diagnosed and treated in the ICU of First Affiliated Hospital of Xinjiang Medical University from June 2018 to June 2020, were selected and were randomly divided into study group(n=270) and control group(n=270). The control group was given standard parenteral nutrition support, and the study group was given L-alanylglutamine adjuvant therapy based on the treatment of the control group. Both groups were treated and observed for 14 days. Results: The incidence(4.8 % and 6.7 %) of undernutrition on the 7th and 14th day of treatment in the study group was significantly lower than that (13.0 % and 17.0 %) in the control group (P<0.05). The serum total protein and albumin content of the two groups after treatment were higher than that before treatment, and the study group was higher than that of the control group, and the differences were statistically significant (P<0.05). The incidence of complications such as lung infection, urinary tract infection, digestive tract reaction, pressure ulcers, etc. during treatment in the study group was 4.8 %, which were significantly lower than that (15.6 %) in the control group (P<0.05). The serum procalcitonin (PCT) value of the two groups after treatment was lower than that before treatment, and the study group was lower than that of the control group, the difference was statistically significant (P<0.05). Conclusion: The application of parenteral nutrition based on L-alanylglutamine in ICU with severe head injury can reduce the incidence of undernutrition and complications, promote the restoration of the body's nutritional status, and inhibit the release of PCT. [ABSTRACT FROM AUTHOR]