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Antibacterial Thermoplastic Polyurethane/PL-DOSS Composite Films.
- Source :
-
Chinese Journal of Polymer Science (Springer Science & Business Media B.V.) . Aug2021, Vol. 39 Issue 8, p1020-1028. 9p. - Publication Year :
- 2021
-
Abstract
- Medical devices-related infections pose a great threat to patients and cause an increased morbidity and mortality. Herein, we prepare an antibacterial composite (TPU-x) through blending medical grade thermoplastic polyurethane (TPU) and the complex (PL-DOSS) of ε-polylysine (ε-PL) and docusate sodium (DOSS). >99% reduction of colony forming unit (CFU) can be obtained in TPU-x composite films even at relatively low content of PL-DOSS, e.g. 0.13% for Methicillin resistant S. aureus (MRSA) and 0.5% for E. coli. The excellent antibacterial activity is mainly attributed to the formation of PL-DOSS nanoparticles that are uniformly dispersed in the TPU matrix with a size of ∼100 nm. TPU-x composite films exhibit long-term stability in saline and good biocompatibility, and retain mechanical properties of TPU. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 02567679
- Volume :
- 39
- Issue :
- 8
- Database :
- Academic Search Index
- Journal :
- Chinese Journal of Polymer Science (Springer Science & Business Media B.V.)
- Publication Type :
- Academic Journal
- Accession number :
- 151386736
- Full Text :
- https://doi.org/10.1007/s10118-021-2578-z