Back to Search
Start Over
Circulating HLA-G and its association with cardiovascular markers in pregnancy.
- Source :
-
Journal of Reproductive Immunology . Aug2021, Vol. 146, pN.PAG-N.PAG. 1p. - Publication Year :
- 2021
-
Abstract
- Human Leukocyte Antigen-G (HLA-G) prevents the activity of immune cells and is decreased in women with preeclampsia. We aimed to investigate the associations between circulating soluble HLA-G (sHLA-G) and 92 cardiovascular disease-related biomarkers from a previously published multiplex study in women with preeclampsia and controls. We found 15 markers significantly associated with circulating sHLA-G in univariate analyses. After multivariable adjusted regression, only proto-oncogene tyrosine-protein kinase Src (SRC) and vascular endothelial growth factor D were significantly associated with sHLA-G. Low SRC, previously observed in the circulation of preeclamptic women, may be regulated by low sHLA-G, and reflect decreased trophoblast differentiation and syncytical formation. [ABSTRACT FROM AUTHOR]
- Subjects :
- *VASCULAR endothelial growth factors
*PREGNANCY
Subjects
Details
- Language :
- English
- ISSN :
- 01650378
- Volume :
- 146
- Database :
- Academic Search Index
- Journal :
- Journal of Reproductive Immunology
- Publication Type :
- Academic Journal
- Accession number :
- 151404202
- Full Text :
- https://doi.org/10.1016/j.jri.2021.103331