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Change in hepatic volume profile in potential live liver donors after lifestyle modification for reduction of hepatic steatosis.
- Source :
-
Abdominal Radiology . Aug2021, Vol. 46 Issue 8, p3877-3888. 12p. - Publication Year :
- 2021
-
Abstract
- Purpose: We aimed to evaluate changes in hepatic volume and hemiliver volume percentage in potential liver donors after hepatic steatosis (HS) reduction through lifestyle modification. Methods: Fifty liver donor candidates with HS (macrovesicular fat [MaF] ≥ 20%) underwent abdominal computed tomography (CT) and liver biopsy before (baseline) and after (follow-up) lifestyle modification. According to the change in MaF, subjects were classified as group A (MaF reduction ≥ 20%, n = 25), and group B (MaF reduction < 20%, n = 25). The hepatic volume and hemiliver volume percentage were measured using CT volumetric analysis. Results: Volume percentage of the left hemiliver + S1 (over the whole liver) significantly increased at follow-up in group A (P < 0.001) but not in group B (P = 0.598). The absolute volume change of the right hemiliver and its percentage change from the baseline were significantly greater than those of the left hemiliver + S1 in group A (P < 0.007). There were no significant differences in these values in group B (P = 0.064 and 0.507, respectively). The percentage of subjects that earned the benefit of becoming suitable donors from the change in hepatic volume distribution caused by HS improvement was 52.0% (13/25) and 40.0% (10/25) in group A and group B, respectively. Regarding posthepatectomy liver failure, none was identified in group A after donation, whereas 12% (3/25) was identified in group B. Conclusion: Hepatic volume profile may change considerably in potential liver donors with HS (MaF ≥ 20%) after HS reduction through lifestyle modification. Reevaluation of the hepatic volume is required before liver procurement after lifestyle modification in these subjects. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 2366004X
- Volume :
- 46
- Issue :
- 8
- Database :
- Academic Search Index
- Journal :
- Abdominal Radiology
- Publication Type :
- Academic Journal
- Accession number :
- 151456943
- Full Text :
- https://doi.org/10.1007/s00261-021-03058-z