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(±)-Rhytidhymarins A and B, two pairs of new isocoumarin derivatives from endophytic fungus Rhytidhysteron sp. BZM-9.
- Source :
-
New Journal of Chemistry . 7/28/2021, Vol. 45 Issue 28, p12700-12704. 5p. - Publication Year :
- 2021
-
Abstract
- Two pairs of isocoumarin derivatives, (±)-rhytidhymarins A and B (1–2), one aromatic ester, rhytidhyster A (3), together with three known compounds (4–6) were isolated from fungus Rhytidhysteron sp. BZM-9. Compounds 1 and 2 are presented as racemates and resolved into optically pure enantiomers (+)-1/(−)-1 and (+)-2/(−)-2 by chiral column separation, respectively. Their planar structures were elucidated by HRESIMS, 1D and 2D NMR data and their absolute configurations were determined by X-ray crystallographic analysis and electronic circular dichroism (ECD) calculation. Compound 5 showed significant cytotoxic activity against SMMC7721 cells with an IC50 value of 0.338 μM and exhibited moderate antimicrobial activity to MRSA with a MIC value of 6.25 μg mL−1; compound 3 showed cytotoxicity against HepG2 cells with an IC50 value of 11.46 μM. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 11440546
- Volume :
- 45
- Issue :
- 28
- Database :
- Academic Search Index
- Journal :
- New Journal of Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 151468603
- Full Text :
- https://doi.org/10.1039/d1nj01993g