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Rapid Oxidation Indoles into 2‐Oxindoles Mediated by PIFA in Combination with n‐Bu4NCl ⋅ H2O.
- Source :
-
Advanced Synthesis & Catalysis . 7/20/2021, Vol. 363 Issue 14, p3532-3538. 7p. - Publication Year :
- 2021
-
Abstract
- We report the development of a rapid approach for directly converting indoles into 2‐oxindoles promoted by HOCl formed in situ from the combination of (bis(trifluoroacetoxy) iodo)benzene (PIFA) and n‐Bu4NCl ⋅ H2O. The procedure is widely functional group tolerant and provides 2‐oxindoles in up to 95% yield within 5 min. The potential applications of the developed methodology are demonstrated by the gram‐scale preparation of 3‐methyl‐2‐oxindole (11 a), the one‐pot two‐step syntheses of spiro‐oxindoles 26 a and 26 b, and the formal synthesis of (‐)‐folicanthine (2). [ABSTRACT FROM AUTHOR]
- Subjects :
- *OXINDOLES
*INDOLE compounds
*OXIDATION
*FUNCTIONAL groups
*BENZENE
Subjects
Details
- Language :
- English
- ISSN :
- 16154150
- Volume :
- 363
- Issue :
- 14
- Database :
- Academic Search Index
- Journal :
- Advanced Synthesis & Catalysis
- Publication Type :
- Academic Journal
- Accession number :
- 151486705
- Full Text :
- https://doi.org/10.1002/adsc.202100234