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Risk of bladder cancer in male Japanese workers exposed to ortho-toluidine and other aromatic amines.
- Source :
-
International Archives of Occupational & Environmental Health . Aug2021, Vol. 94 Issue 6, p1427-1439. 13p. - Publication Year :
- 2021
-
Abstract
- Purpose: Nine bladder cancer (BCa) cases were reported among aromatic amine-exposed male workers at a factory manufacturing organic dye/pigment intermediates in Japan. We aimed to evaluate the characteristics of aromatic amine-exposed workers by cross-sectional observation, and the risk of BCa by assessing the standardized incidence ratio (SIR). Methods: In the cross-sectional study, our subjects were: 9 BCa patients, 36 aromatic amine-exposed non-patients, and 79 non-exposed workers from 3 factories. We evaluated the subjects' medical history, urinalysis, qualitative determination of nuclear matrix protein 22, and urinary cytology. For SIR assessment, 98 aromatic amine-exposed workers from 1 factory were included, and the Japanese general male population was used as a referent population. Since no direct aromatic amine-exposure data were available, we calculated surrogate exposure levels using information on job sites, exposure potency, and duration. Results: Coexistent aromatic amines were ortho-toluidine (OT), aniline, para-toluidine, ortho-anisidine, 2,4-xylidine, and ortho-chloroaniline. The prevalence rates of cystitis and bladder lesion-related symptoms in both BCa patients and aromatic amine-exposed non-patient workers were significantly higher than those of non-exposed workers. Overall, the SIR for BCa in OT-exposed workers was 56.8 (95% CI 27.7–104.3) and apparent dose–response relationships were revealed between the SIR and the surrogate exposure level in the 0–10-year lagged analyses. Overall, SIRs in other aromatic amine-exposed workers were also significantly high but no or unclear dose–response relationships were observed. Conclusions: We conclude that OT may be responsible for the increased risk of BCa. Regular monitoring of bladder lesion-related symptoms is essential for the early identification of BCa. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 03400131
- Volume :
- 94
- Issue :
- 6
- Database :
- Academic Search Index
- Journal :
- International Archives of Occupational & Environmental Health
- Publication Type :
- Academic Journal
- Accession number :
- 151490646
- Full Text :
- https://doi.org/10.1007/s00420-021-01658-2