Visible-light excitable Eu3+-induced hyaluronic acid-chitosan aggregates with heterocyclic ligands for sensitive and fast recognition of hazardous ions.

Water-soluble luminescent lanthanide complexes that can be excited with visible light could enable rapid detection of toxic anions and cations in biological systems. Eu3+-induced hyaluronic acid-chitosan aggregates (EIHCA) can improve the stability, biocompatibility, efficiency, and light absorption of luminescent Eu3+ complexes. Visible-range excitation may avoid phototoxicity associated with overexposure to UV light in biological and ecological applications. In this work, we synthesized and characterized series of EIHCA complexes having three N -donor heterocyclic ligands: 2,9-dimethyl-4,7-diphenyl-1,10-phenanthroline (Dphen), 2,2′: 6′,2″-terpyridine (Tpy) and 1,10-phenanthroline monohydrate (Phen). These complexes possessed bright red fluorescence with a visible range excitation maximum. The photophysical properties of one formulation (we denote as EDL6) include fast quenching response (20 s) of the fluorescence, multi-selectivity, low limit of detection, and high quenching (K sv) values, enabling selective, rapid and sensitive recognition of Cr 2 O 7 2− and Fe3+ in aqueous solution. Furthermore, EDL6 exhibits cytocompatibility with mammalian cells that make these complexes promising biocompatible candidate as a safe replacement of organic fluorophores for fluorescence sensing applications. Thus, these new EIHCA complexes were successfully employed for the selective detection of hazardous materials in biological and aqueous environment samples. [Display omitted] • Eu3+-induced hyaluronic acid-chitosan aggregate containing a combination of N -heterocyclic ligands, were synthesized. • These nanoparticles serve as fluorescent sensors with visible-range excitation, water stability and bio-compatibility. • Eu3+-complexes are fast and multi-responsive fluorescence sensors to detect Cr(VI) and Fe(III) in water. • Eu3+-fluorescent complex exhibits cell membrane permeability enabling detection of ions in live cell cultures. [ABSTRACT FROM AUTHOR]