Oxidative Halogenation of Lappaconitine and N-Deacetyllappaconitine HCl and HBr in the Presence of H2O2.

Oxidative halogenation of lappaconitine and N-deacetyllappaconitine HBr or HCl in the presence of H2O2 in MeOH was associated upon bromination by N-20-deethylation and produced the 3′,5′-dibromo derivative of N-20-nordeacetyllappaconitine; upon chlorination, a mixture of 5′-mono- and 3′,5′-dichloro derivatives of N-deacetyllappaconitine with the monochloro-derivative dominating. [ABSTRACT FROM AUTHOR]